Dangers of Barbiturates

Barbiturates.

Possible Dangers of Tracheobronchial Suctioning

یکی از مراقبت های روزمره که در بخش های ICU انجام می شود، خارج کردن ترشحات مجاری تنفسی بوسیله ساکشن تراکئوبرونکیال می باشد. بیمارانی به این کار نیاز پیدا می کنند که اختلالی در رفلکس معمولی سرفه داشته باشند مثل مبتلایان به بیماریهای تنفسی و عصبی یا بیمارانی که به علت استفاده از ماشین تنفس مصنوعی ونتیلاتور) مجبورند از داروهای متوقف کننده رفلکس سرفه و یا شل کننده ها استفاده کنند. این پروستیجر از طر...

Comparative depression of several short acting barbiturates and spiro-barbiturates.

In an effort to develop new and possibly better types of barbiturates, suitable for intravenous use, a large number of spiro-barbiturates have been prepared by a ring closure on the 5-carbon atom of the barbituric acid and afforded for pharmacologic study. Spiro(2'-ethyl-3',5'-dimethyl cyclopentane) thio-barbituric acid appears to be the most promising product of a series of 50 analogues. Stoel...

Mechanism of action of barbiturates.

Despite the widespread use of barbiturates and their clear potential for abuse, little is known of their neurochemical mechanisms of action. Our purpose is to review the neurochemical effects of acute and chronic barbiturate administration, with particular emphasis on the relationship between neurochemical changes and the development of tolerance and dependence. The electrophysiological effects...

Barbiturates and oxidative phosphorylation.

It has been claimed that barbiturates uncouple oxidative phosphorylations (Brody & Bain, 1954; Brody, 1955). These authors have demonstrated that during the oxidation of pyruvate by liver and brain mitochondria, phosphate uptake was lowered proportionately more than oxygen uptake. Support for the uncoupling theory was derived from certain similarities between the barbiturates and 2:4dinitrophen...